Clinical Research

Regenerative therapy represents one of the most interesting and promising areas within healthcare. Below, you’ll find several studies detailing the efficacy of regenerative medicine in orthopedic conditions.



Orthopedic conditions refers to a range of conditions having to do with bone and connective tissue, including breaks, tears in tendons and ligaments, and degeneration of cartilage. Leading to pain and movement limitations, orthopedic conditions can benefit from regenerative therapies that can help heal bones, regrow cartilage, and reduce pain.


Degenerative Disc Disease

Mesenchymal Stem Cells (MSCs) display long-term proliferation, efficient self-renewal, and multipotent differentiation. Because of these characteristics, MSCs may have the ability to stop and reverse degeneration of spinal discs. Some studies have shown anincrease in disc height, disc water content, and gene expression. One of the main biological functions of MSCs is their ability to reproduce cartilage and bone tissue cells (multipotent differentiation capability). This is important in degenerative disc disease, since a large number of cells from the outer ring (annulus fibrosus) and the inner gelatinous (nucleus pulposus) of the discs are of a cartilaginous nature.

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Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multi-lineage potential to differentiate into cell types of mesodermal origin. Due to this attribute, MSCs can differentiate into chondrocytes, which are later replaced by bone. These cells may repair the subchondral bone without any loss of articular cartilage at the surface. MSCs have shown to therapeutically alter the progression of OA by down-regulating the release and expression of the main OA inflammatory factors and chemokines (signaling proteins secreted by cells) directly involved in the progression of the disease. According to the literature, there are reports of significant improvements in joint function, reduction in pain, and an increase of cartilage in the affected joint.

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